Nerve bundles, together with arterioles and venules, are found in great quantity in neurovascular bundles of the dermis. Meissner corpuscles, found in the dermal papillae, help to mediate touch and are found predominantly on the ventral sides of the hands and feet. Meissner corpuscles occur in greater abundance on the hands, with greatest concentration in the fingertips. Vater-Pacini corpuscles are large nerveend organs that generate a sense of pressure and are located in the deeper portion of the dermis of weight-bearing surfaces and genitalia. They also are found commonly in the nipple and anogenital region. Pain, temperature, and itch sensation are
transmitted by unmyelinated nerve fibers that end around hair follicles and the papillary dermis.

Vasoconstriction is regulated by the postganglionic adrenergic fibers of the autonomic nervous system. This system regulates the apocrine gland secretions and the contraction of AP muscles of hair follicles. Eccrine sweat secretions, on the other hand, are mediated by cholinergic fibers.

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