Nerve bundles, together with arterioles and venules, are found in great quantity in neurovascular bundles of the dermis. Meissner corpuscles, found in the dermal papillae, help to mediate touch and are found predominantly on the ventral sides of the hands and feet. Meissner corpuscles occur in greater abundance on the hands, with greatest concentration in the fingertips. Vater-Pacini corpuscles are large nerveend organs that generate a sense of pressure and are located in the deeper portion of the dermis of weight-bearing surfaces and genitalia. They also are found commonly in the nipple and anogenital region. Pain, temperature, and itch sensation are
transmitted by unmyelinated nerve fibers that end around hair follicles and the papillary dermis.